Complications of colectomy before liver transplant in PSC

What is known

• In PSC-IBD patients with cirrhosis undergoing colectomy, 19 of 23 (82.6%) developed postoperative complications; there were no differences in morbidity or mortality between pouch and colectomy-with-ileostomy patients. ¹
• In a separate series, wound infection occurred in 8 of 32 patients within 30 days of ileal pouch surgery, and there was no 30-day perioperative mortality despite MELD scores of 6–20. ²

What is unknown / caveats

• The 82.6% figure is the overall complication rate in a small single cohort, not specifically a 30-day rate limited to pre-transplant patients
• Only 8 of 23 patients in that cohort were on the transplant list; the reported complication rate is not broken out for that subgroup
• The retrieved excerpts do not report a specific 30-day postoperative complication proportion restricted to PSC patients undergoing colectomy before transplant.

References

1. Lian L, Menon KV, Shen B, Remzi F, Kiran RP. Inflammatory bowel disease complicated by primary sclerosing cholangitis and cirrhosis: is restorative proctocolectomy safe?. Dis Colon Rectum. 2012;55(1):79-84. PMID: 22156871.

2. Mathis KL, Dozois EJ, Larson DW, Cima RR, Sarmiento JM, Wolff BG, Heimbach JK, Pemberton JH. Ileal pouch-anal anastomosis and liver transplantation for ulcerative colitis complicated by primary sclerosing cholangitis. Br J Surg. 2008;95:882-6. PMID: 18496886.

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Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct.