Top 100 Most-Cited Papers

The 100 most-cited papers across the IBD-PSC literature, by citation count (NIH Open Citation Collection).

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

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1Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol
1,019
2Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.
Rutter M · 2004 · Gastroenterology
973
3Intestinal inflammation and cancer.
Ullman TA · 2011 · Gastroenterology
912
4Diagnosis and management of primary sclerosing cholangitis.
Chapman R · 2010 · Hepatology
875
5Gallbladder cancer: epidemiology and outcome.
Hundal R · 2014 · Clin Epidemiol
831
6Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
Chapman RW · 1980 · Gut
739
7Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection.
Endo I · 2008 · Ann Surg
718
8Risk factors for cholangiocarcinoma.
Tyson GL · 2011 · Hepatology
710
9Primary sclerosing cholangitis - a comprehensive review.
Karlsen TH · 2017 · J Hepatol
662
10Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G · 2021 · Gastroenterology
643
11Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
Ellinghaus D · 2016 · Nat Genet
579
12The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease.
Harbord M · 2016 · J Crohns Colitis
570
13The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study.
Bernstein CN · 2001 · Am J Gastroenterol
565
14PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis.
Loftus EV · 2005 · Gut
557
15Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis.
Boonstra K · 2013 · Hepatology
557
16Hepatic and extrahepatic malignancies in primary sclerosing cholangitis.
Bergquist A · 2002 · J Hepatol
524
17Ulcerative Colitis in Adults: A Review.
Gros B · 2023 · JAMA
515
18Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis.
Wiesner RH · 1989 · Hepatology
505
19Extraintestinal Manifestations of Inflammatory Bowel Disease.
Vavricka SR · 2015 · Inflamm Bowel Dis
491
20Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas.
Kawaguchi K · 1991 · Hum Pathol
466
21Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review.
Boonstra K · 2012 · J Hepatol
458
22Primary sclerosing cholangitis.
Hirschfield GM · 2013 · Lancet
451
23Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis.
Soetikno RM · 2002 · Gastrointest Endosc
437
24Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study.
Gregorio GV · 2001 · Hepatology
437
25An update on the epidemiology of inflammatory bowel disease in Asia.
Thia KT · 2008 · Am J Gastroenterol
436
26Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database.
Vind I · 2006 · Am J Gastroenterol
430
27Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years.
Jess T · 2012 · Gastroenterology
422
28Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort.
Vavricka SR · 2011 · Am J Gastroenterol
419
29Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.
Weismüller TJ · 2017 · Gastroenterology
408
30Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis.
Burak K · 2004 · Am J Gastroenterol
394
31Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.
Pardi DS · 2003 · Gastroenterology
393
32Current concepts. Primary sclerosing cholangitis.
LaRusso NF · 1984 · N Engl J Med
373
33Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis.
Penna C · 1996 · Gut
371
34Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
Nakamoto N · 2019 · Nat Microbiol
357
35ACG Clinical Guideline: Primary Sclerosing Cholangitis.
Lindor KD · 2015 · Am J Gastroenterol
357
36The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls.
Kummen M · 2017 · Gut
350
37Primary sclerosing cholangitis.
Dyson JK · 2018 · Lancet
349
38Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies.
Lakatos PL · 2008 · World J Gastroenterol
344
39Extraintestinal manifestations of inflammatory bowel disease.
Levine JS · 2011 · Gastroenterol Hepatol (N Y)
338
40Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.
Tung BY · 2001 · Ann Intern Med
335
41Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential.
Broomé U · 1995 · Hepatology
334
42Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD.
Sabino J · 2016 · Gut
331
43Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH · 2004 · Gastroenterology
322
44Recent insights into the genetics of inflammatory bowel disease.
Cho JH · 2011 · Gastroenterology
321
45Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community.
Bambha K · 2003 · Gastroenterology
319
46Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial.
Rosenzwajg M · 2019 · Ann Rheum Dis
318
47Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Triantafillidis JK · 2009 · Anticancer Res
316
48Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
Liu JZ · 2013 · Nat Genet
314
49Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis.
Olsson R · 1991 · Gastroenterology
311
50Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis.
Kim ER · 2014 · World J Gastroenterol
309
51Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE · 2013 · Gastroenterology
306
52High lifetime risk of cancer in primary sclerosing cholangitis.
Claessen MM · 2009 · J Hepatol
292
53Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis.
Duerr RH · 1991 · Gastroenterology
288
54Primary sclerosing cholangitis: findings on cholangiography and pancreatography.
MacCarty RL · 1983 · Radiology
286
55Predictive and protective factors associated with colorectal cancer in ulcerative colitis: A case-control study.
Velayos FS · 2006 · Gastroenterology
282
56Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
Bajer L · 2017 · World J Gastroenterol
280
57Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
Ji SG · 2017 · Nat Genet
279
58Genome-wide association analysis in primary sclerosing cholangitis.
Karlsen TH · 2010 · Gastroenterology
278
59Risk and natural history of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis.
Brentnall TA · 1996 · Gastroenterology
256
60Diagnosis and classification of ulcerative colitis.
Conrad K · 2014 · Autoimmun Rev
255
61Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis.
Eksteen B · 2004 · J Exp Med
254
62Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease.
Eaden JA · 2002 · Gut
253
63Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis.
Graziadei IW · 1999 · Hepatology
253
64Primary sclerosing cholangitis. A study of forty-two cases.
Warren KW · 1966 · Am J Surg
251
65Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States.
Maisonneuve P · 2013 · J Natl Cancer Inst
247
66The epidemiology of inflammatory bowel disease.
Burisch J · 2015 · Scand J Gastroenterol
246
67Non-alcoholic duct destructive chronic pancreatitis.
Ectors N · 1997 · Gut
244
68Elevated serum IgG4 concentration in patients with primary sclerosing cholangitis.
Mendes FD · 2006 · Am J Gastroenterol
243
69The intestinal barrier: a pivotal role in health, inflammation, and cancer.
Neurath MF · 2025 · Lancet Gastroenterol Hepatol
242
70Primary sclerosing cholangitis: a long-term follow-up study.
Aadland E · 1987 · Scand J Gastroenterol
241
71Orthotopic liver transplantation for primary sclerosing cholangitis. A 12-year single center experience.
Goss JA · 1997 · Ann Surg
239
72Cancer in inflammatory bowel disease.
Xie J · 2008 · World J Gastroenterol
238
73Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study.
Chalasani N · 2000 · Hepatology
236
74Molecular Pathogenesis of Cholangiocarcinoma.
Labib PL · 2019 · BMC Cancer
235
75Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Kallenberg CG · 1992 · Am J Med
232
76Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study.
Rubin DT · 2013 · Clin Gastroenterol Hepatol
230
77The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis.
Trauner M · 2019 · Hepatology
229
78Colorectal Cancer in Inflammatory Bowel Disease.
Stidham RW · 2018 · Clin Colon Rectal Surg
227
79Association of primary sclerosing cholangitis with HLA-B8.
Chapman RW · 1983 · Gut
227
80Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study.
Lakatos L · 2003 · World J Gastroenterol
223
81Relationship of inflammatory bowel disease and primary sclerosing cholangitis.
Fausa O · 1991 · Semin Liver Dis
223
82Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation.
Boberg KM · 2002 · Scand J Gastroenterol
221
83MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease).
Grant AJ · 2001 · Hepatology
220
84Ulcerative colitis-associated colorectal cancer.
Yashiro M · 2014 · World J Gastroenterol
217
85Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma.
Zhang Q · 2021 · Cancer Discov
217
86Cancer surveillance in patients with primary sclerosing cholangitis.
Razumilava N · 2011 · Hepatology
217
87A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts.
Alabraba E · 2009 · Liver Transpl
214
88Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population.
Ponsioen CY · 2002 · Gut
214
89The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis.
Shetty K · 1999 · Am J Gastroenterol
213
90Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis.
Ludwig J · 1981 · Hepatology
210
91Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management.
Larsen S · 2010 · Ann Med
206
92Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis.
Nilsson HO · 2000 · J Clin Microbiol
202
93The epidemiology and the pathogenesis of inflammatory bowel disease.
Karlinger K · 2000 · Eur J Radiol
201
94Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria.
Zen Y · 2007 · Mod Pathol
201
95Primary sclerosing cholangitis, the biliary tree, and ulcerative colitis.
Thorpe ME · 1967 · Gut
200
96Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses.
Vieira-Silva S · 2019 · Nat Microbiol
199
97Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis: a case-control study.
Bergquist A · 1998 · Hepatology
198
98Prognostic Factors for Advanced Colorectal Neoplasia in Inflammatory Bowel Disease: Systematic Review and Meta-analysis.
Wijnands AM · 2021 · Gastroenterology
195
99High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.
Eaton JE · 2011 · Am J Gastroenterol
195
100Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial.
Allegretti JR · 2019 · Am J Gastroenterol
193